Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4
✍ Scribed by David Turgeon; Jean-Sébastien Carrier; Éric Lévesque; Barbara G Beatty; Alain Bélanger; Dean W Hum
- Book ID
- 115629886
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 488 KB
- Volume
- 295
- Category
- Article
- ISSN
- 0022-2836
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UGT2B17 and UGT2B28 are among the most commonly deleted genes in humans and encode members of the uridine diphosphate (UDP)-glucuronosyltransferase 2B (UGT2B) subfamily. They are involved, along with UGT2B15, in the catabolism of sex-steroid hormones. Despite the recent biomedical interest in UGT2B1
Cytochrome P450 genes from the CYP2A, CYP2B, and C Y P 2 F subfamilies form a tight cluster which we have localized on the detailed physical map of human chromosome 19. The corresponding three gene subfamilies are also clustered in the mouse genome, on the region of chromosome 7 known to be syntenic