Isolation and characterization of the bioactive circulating human parathyroid hormone, hPTH-1–37
✍ Scribed by Dieter Hock; Markus Mägerlein; Gabi Heine; Peter P Ochlich; Wolf-Georg Forssmann
- Book ID
- 117106911
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 522 KB
- Volume
- 400
- Category
- Article
- ISSN
- 0014-5793
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The pharmacokinetics (PK) and hepatic extraction (E(H)) of human PTH (1-34), hPTH (1-34), were characterized in rat, dog, and monkey, following intraportal (IPO) and intravenous (IV) bolus administration. hPTH (1-34) was administered to Sprague-Dawley rats (2, 10, 100 microg/kg), beagle dogs (3, 6 m
## Abstract The N‐terminal 1–34 fragment of parathyroid hormone (PTH) elicits the full spectrum of bone‐related biological activities of the intact native sequences. It has been suggested that the structural elements essential for bioactivity are two helical segments located at the N‐terminal and C