Isolation and characterization of poly-N-acetyllactosaminylceramides accumulated in the erythrocytes of congenital dyserythropoietic anemia type II patients

✍ Scribed by Michiko N. Fukuda; Brian Bothner; Paolo Scartezzini; Anne Dell

• Book ID: 103038827
• Publisher: Elsevier Science
• Year: 1986
• Tongue: English
• Weight: 850 KB
• Volume: 42
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(86)90052-6

✦ Synopsis

Congenital dyserythropoietic anemia type II or hereditary erythroblastic polynuclearity with positive acidified serum test (HEMPAS) is a rare genetic disease inherited by a recessive mode. Previous studies on HEMPAS erythrocytes have shown that Band 3 and Band 4.5 glycoproteins were not glycosylated by lactosaminoglycans, while polylactosaminyl carbohydrates are accumulated as glycolipids (P.