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Isolation and characterization of a variant of human papillomavirus type 11 from a nasal inverting (schneiderian) papilloma

✍ Scribed by Alan Pater; Humphrey Gardner; Don S. Respler; Anthony Jahn; Mary M. Pater

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
524 KB
Volume
25
Category
Article
ISSN
0146-6615

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✦ Synopsis

We have previously reported the presence of a variant of human papillomavirus (HPV) type 1 1 in a nasal inverting papilloma [Respler et al., 19871. In the present study, we have cloned molecularly the DNA of this variant at its unique restriction enzyme Bum HI site into lambda BFlOl phage. Restriction enzyme mapping and DNA sequencing revealed that the genome of this virus contained an extra 531 base pair (bp) which was the repeat of most of the noncoding region (ncr) of HPV 11. Insertion of transcriptional control elements, including the repeated sequence, in front of the chloramphenicol acetyltransferase (CAT) gene resulted in a 5to 30-fold increase in expression in transfected cells, as compared to the constructs containing a single ncr of HPV 1 1. This increased expression was due to enhanced levels of CAT RNA the synthesis of which is initiated by the viral promoter element.

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