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Isolation and characterization of a heparin with high anticoagulant activity from Anomalocardia brasiliana

✍ Scribed by Dietrich, Carl P.; de Paiva, JoséF.; Moraes, Carlos T.; Takahashi, Helio K.; Porcionatto, Marimélia A.; Nader, Helena B.


Book ID
123129001
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
572 KB
Volume
843
Category
Article
ISSN
0304-4165

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The synthesis of tri-N-acetylated heparin pentasaccharide 2 is described. It was assembled from five suitably blocked monosaccharide units (S7). Glucuronic-acid building block 4 was prepared from glucose by direct Jones oxidation of the 6-0-trityl derivative 18. The resulting acid 16 was esterified