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Isolation and biochemical characterization ofStreptomyces clavuligerusmutants in the biosynthesis of clavulanic acid and cephamycin C

✍ Scribed by Jorge Romero; Paloma Liras; Juan F. Martín


Publisher
Springer
Year
1988
Tongue
English
Weight
472 KB
Volume
27
Category
Article
ISSN
1432-0614

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✍ Thomas D. Stamato; David Patterson 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 798 KB

## Abstract A mutant (A204) of Chinese hamster ovary cells (CHO‐K1), which is deficient in dihydroorotate (DHO) dehydrogenase (E.C. 1.3.3.1) activity, has been isolated by a replica plating procedure. The mutant does not show a requirement for exogenously added pyrimidines. Examination of intact ce