Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22
โ Scribed by Nicole P. Curtiss; Jeannette M. Bonifas; Jennifer O. Lauchle; Jason D. Balkman; Christian P. Kratz; Brooke M. Emerling; Eric D. Green; Michelle M. Le Beau; Kevin M. Shannon
- Book ID
- 116981386
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 236 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0888-7543
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## Abstract Deletion of the long arm of chromosome 9, del(9q), is a recurring chromosomal aberration in acute myeloid leukemia (AML) that is frequently associated with t(8;21). The critical gene products affected by del(9q) are unknown but likely cooperate with the __AML1/ETO__ fusion gene created
The candidate tumor-suppressor gene ING1 encodes p33 ING1 , a nuclear protein which physically interacts with TP53. It has been shown that p33 ING1 acts in the same biochemical pathway as TP53, leading to cell growth inhibition. Interestingly, a rearrangement of the ING1 gene was found in a neurobla