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Isolated soluble fractions from spleen cell culture supernatants induce tumor enhancement

✍ Scribed by Ana María Eiján; Mariaa Adela Jasnis; Alicia Beatriz Motta; Sara Oisgold-Dagá

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
396 KB
Volume
41
Category
Article
ISSN
0022-4790

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✦ Synopsis

Supernatants of spleen cell culture from small-tumor-bearing mice, largetumor-bearing mice, and large-tumor resected mice were fractionated by Sephadex G-100. The biological activity on tumor growth of all fractions was tested in vivo. It was found that only one fraction (MW: 220-250 kD) from spleen cell supernatants of small-tumor-bearing mice or large-tumor resected mice enhanced tumor growth. In spleen cell supernatants from large-tumor-bearing mice, two fractions had enhancing activity (MW: 220-250 and 100-10 kD). Thus, the surgical resection of large tumor induced disappearance of enhancing activity from the fraction of lower molecular weight.

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## Abstract Sera from tumor‐bearing mice induce specific cytotoxicity to tumor cells by non‐immune lymphoid cells (antiserum‐dependent cytotoxicity or ADC). When spleen cells from BALB/c mice bearing autochthonous or syngeneic sarcomas were cultured in vitro, culture supernatants were obtained whic