๐”– Bobbio Scriptorium
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Isolated growth cones stimulate proliferation of cultured Schwann cells

โœ Scribed by Erik W. Dent; James A. Ida Jr; Dr. Jun E. Yoshino

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
762 KB
Volume
5
Category
Article
ISSN
0894-1491

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โœฆ Synopsis

Abstract

A growth coneโ€enriched fraction was prepared from 3โ€“4 day rat cerebra. Examination of the growth cone fraction by electron microscopy revealed numerous structures circular in appearance that contain a number of features common to neuronal growth cones in vivo. The isolated growth cones stimulated a doseโ€dependent incorporation of [^3^H]โ€thymidine into cultured Schwann cells in a manner similar to that observed with an axolemmaโ€enriched fraction prepared from adult rat brainstem. The mitogenic activities of both the growth cone fraction and axolemmaโ€enriched fraction were decreased 50% and 20%, respectively, by treatment with heparitinase I. The mitogen for Schwann cells present in the isolated growth cones appears to be similar to that found in axolemmaโ€enriched fractions prepared from adult rats.

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