Isolated central nervous system relapse of testicular cancer

✍ Scribed by Perry, James J. ;Jelinek, James S.

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 596 KB
• Volume: 20
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950200115

✦ Synopsis

Abstract

Central nervous system involvement with testicular cancer usually occurs with advanced systemic disease. Isolated CNS disease at relapse is rare. We report a patient who developed a solitary brain metastasis with no other systemic disease after having achieved a complete response to frontline therapy. After combined modality therapy for the CNS disease, the patient has remained disease‐free for more than 3 years. The literature regarding brain metastases in relapsed testicular cancer is reviewed, including nine cases of isolated brain metastases. The CNS can be a “sanctuary” site for testicular cancer, and in the unusual subset of patients with isolated brain relapse, long‐term remission is possible with aggressive therapy.