Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase deficiency in two sibs

✍ Scribed by F. A. Beemer; K. Bartlett; M. Duran; H. K. Ghneim; S. K. Wadman; L. Bruinvis; D. Ketting

• Publisher: Springer
• Year: 1982
• Tongue: English
• Weight: 476 KB
• Volume: 138
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00442517

✦ Synopsis

Two Vietnamese siblings with an isolated deficiency of 3-methylcrotonyl coenzyme A carboxylase in leucocytes and cultured fibroblasts are described. Both children excreted massive amounts of 3-methylcrotonylglycine and 3-hydroxyisovaleric acid. There was no in vivo or in vitro biochemical response to biotin. Apart from an attack of vomiting leading to subcoma in the elder sib four weeks after arrival in the Netherlands, the children were in good health. There were no signs of delayed mental development.