Isolated angiitis of the central nervous system: involvement of penetrating vessels at the base of the brain

✍ Scribed by Patrick Stübgen; Barend P. Lotz

• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 895 KB
• Volume: 238
• Category: Article
• ISSN: 0340-5354
• DOI: 10.1007/bf00314788

✦ Synopsis

Isolated angiitis of the central nervous system (IAC) was diagnosed in a 40-year-old Caucasian male by histological examination of a leptomeningeal biopsy specimen, and the exclusion of systemic inflammatory or infective disease. Therapy with prednisone 30 mg/day and cyclophosphamide 100 mg/day resulted in clinical and radiological improvement, which have been maintained for an 8-month follow-up period. Magnetic resonance imaging (MRI) showed lesions implicating involvement of specific penetrating vessels at the base of the brain, an unusual complication of IAC, and allowed an accurate MRI-clinical correlation.