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Isoflurane and Propofol Block Neurotoxicity Caused by MK-801 in the Rat Posterior Cingulate/Retrosplenial Cortex

✍ Scribed by Jevtovi??-Todorovic, Vesna; Kirby, Charity O.; Olney, John W.

Book ID: 110078759
Publisher: Nature Publishing Group
Year: 1997
Tongue: English
Weight: 798 KB
Volume: 17
Category: Article
ISSN: 0271-678X
DOI: 10.1097/00004647-199702000-00006

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MK-801 is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist which can prevent excitatory neuronal death. At higher concentrations, however, it can also induce neuronal death in the limbic system. This MK-801-induced selective neurotoxicity has been proposed as an animal model for dem