In vitro activation of cyclophosphamide
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Helene Z. Hill; George J. Hill
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Article
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1984
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John Wiley and Sons
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English
β 486 KB
The problem of activation of cyclophosphamide (CY) for an in vitro chemosensitivity assay was studied using the B16 melanoma. The efficacy of the S9 hepatic microsomal fraction in vitro was compared with activation by passage of drug in vivo. The effect of CY was assayed by inhibition of tritiated t