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Isoenzyme-selective cyclic nucleotide phosphodiesterase inhibitors: Effects on airways smooth muscle

✍ Scribed by David Raeburn; Charles Advenier


Book ID
116175231
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
845 KB
Volume
27
Category
Article
ISSN
1357-2725

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πŸ“œ SIMILAR VOLUMES


Cyclic nucleotide phosphodiesterase (PDE
✍ Truss, M. C. ;οΏ½ckert, S. ;Stief, C. G. ;Kuczyk, M. ;Jonas, U. πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 575 KB

Phosphodiesterases (PDEs) are key enzymes involved in the regulation of intracellular cyclic nucleotide metabolism. The aim of the present study was to identify and to characterize the PDE isoenzymes present in the human detrusor smooth muscle. Human detrusor PDE isoenzymes were separated by Q-Sepha

Cyclic nucleotide phosphodiesterase (PDE
✍ Truss, M. C. ;οΏ½ckert, S. ;Stief, C. G. ;Forssmann, W. G. ;Jonas, U. πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 585 KB

Phosphodiesterases (PDEs) regulate intracellular cyclic nucleotide metabolism and, thus, contraction and relaxation of smooth musculature. The aim of the present study was to evaluate the functional effects of isoenzyme-selective inhibitors and their effects on cyclic nucleotide levels in the human