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Isoelectric focusing analysis of detergent extracted renal 11β-hydroxysteroid dehydrogenase

✍ Scribed by W. Schulz; I. Lichtenstein; H. Siebe; K. Hierholzer


Book ID
116007643
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
996 KB
Volume
32
Category
Article
ISSN
0022-4731

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## Abstract Renal 11β‐hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11β‐keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibit