Isodicentric X chromosome in a patient with myelodysplastic syndrome
β Scribed by Robert John Morgan; Donald William Milligan; Jeffrey Williams
- Book ID
- 119103382
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 443 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0165-4608
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Cytogenetic analyses have previously shown that the region Xq11.2-q21 is retained in all structurally abnormal X chromosomes. From these observations the conclusion has been drawn that this "critical region" on the proximal long arm of the X chromosome contains the locus controlling X-inactivation.
This paper presents a female patient with primary amenorrhea in whose karyotype an aberrant X chromosome was present. The chromosome resulted from the fusion of two X chromosomes at distal parts of the long arm and from the loss of the segment q24 leads to qter. The clinical and cytogenetic picture
## Abstract We report on an adult male with Klinefelter phenotype and an isodicentric Y chromosome (47,XX,+idic(Y)(q12)), a combination which has to the best of our knowledge not been reported before. The patient was hospitalized in forensic psychiatry because of repeated delinquency, aggressive, a