Isochromosome 1q in acute monocytic leukemia: A new nonrandom association

✍ Scribed by Jacqueline M. Hawkins; Marion Wood; Faith Wright; Dr. Lorna M. Seeker-Walker

• Book ID: 102221146
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 253 KB
• Volume: 5
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870050213

✦ Synopsis

Abstract

We report a case of de novo acute monocytic leukemia in a 25‐year‐old man in whom the sole clonal cytogenetic abnormality was an additional isochromosome Iq. Cytogenetic polymorphisms indicate that, in addition to the formation of the isochromosome, a duplication of the remaining normal chromosome I had taken place. Other reported cases suggest an association between acute monocytic leukemia and i(lq).