Isobolographic assessment of the convulsant interaction between theophylline and caffeine or pentylenetetrazol in rats

Extension of the isobolographic approach

Extension of the isobolographic approach to interactions studies between more than two drugs: Illustration with the convulsant interaction between pefloxacin, norfloxacin, and theophylline in rats

✍ Céline Brochot; Sandrine Marchand; William Couet; Andrew Gelman; Frédéric Y. Boi 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB 👁 1 views

This work proposes a model to characterize the additivity or the nonadditivity of combinations of more than two agents. Using a Bayesian framework, we modeled the variability between experimental subjects, the errors that occurred during data collection, and the relationship between effects and conc