ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection

✍ Scribed by Julie C Baker-LePain; Robyn C Reed; Christopher V Nicchitta

• Book ID: 104359128
• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 294 KB
• Volume: 15
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952791502000067

✦ Synopsis

Heat shock/chaperone protein (HSCP)±peptide complexes can access the cross-priming pathways of antigen presenting cells (APCs), and the gp96-associated peptides can be re-presented on APC MHC class I molecules to elicit CD8 T cell activation. This immunological circuit is thought to provide the functional basis for HSCP function in tumor immunity. Recent ®ndings identifying a `natural adjuvant' function for HSCPs suggest complementary, or perhaps alternative, mechanisms of HSCP-mediated tumor rejection.