Islet amyloid may have a pathological role in the development of Type 2 (non-insulin-dependent) diabetes mellitus. The prevalence of islet amyloid has been investigated on post-mortem pancreatic tissue from both diabetic and non-diabetic Pima Indian subjects who had previously been assessed by oral
Islet cell antibodies and diabetes mellitus in Pima Indians
β Scribed by W. C. Knowler; P. H. Bennett; G. F. Bottazzo; Deborah Doniach
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 362 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0012-186X
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Among the population of Nauru there is a high prevalence of diabetes with onset in early adult life. To ascertain whether autoimmunity to islet cell antigens contributes to this diabetes, a population survey of serum autoantibodies was performed. Subjects were grouped into euglycaemic control subjec
In a cross-sectional study, sera of 81 adult diabetic in-patients were tested for the presence of pancreatic islet cell antibodies (ICA), both IgG and complement-fixing. All patients had been well controlled initially with oral hypoglycaemic agents and therefore had been classified as having Type 2
Glycated haemoglobin could offer several practical advantages over the OGTT for assessing glucose metabolism. Initial cross-sectional studies (1983)(1984)(1985) on 381 subjects (mostly Pima Indians) described the relationship between HbAlc (a specific glycated Hb) and the OGTT. We performed follow-u