Ischämie/Reperfusionsschaden der Leber durch freie radikale — direkter radikalnachweis mittels elektronenspinresonanz (ESR)
✍ Scribed by R. Kunz; H. A. Brune; U. Ziegler; M. Marzinzig; H. G. Beger
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 496 KB
- Volume
- 376
- Category
- Article
- ISSN
- 1435-2451
No coin nor oath required. For personal study only.
✦ Synopsis
The generation of free oxygen radicals is presumed to be a pathogenetic principle in various conditions, primarily in postischemic reperfusion injury. Their assessment is difficult. ESR is an excellent tool to assess free radicals directly. In an experimental model of rat liver ischemia and reperfusion the increased generation of free radicals during reperfusion in liver tissue could be demonstrated after 60 min of liver ischemia. Elevated production rates of radicals could be detected after 5 min of reperfusion for at least 45 min with a maximum after 15 min of reperfusion. Scavenging of these radicals has to start in the very beginning of reperfusion.