Ischaemia and mediator release: Interrelationship in antigen-challenged sensitized guinea-pig kidney
✍ Scribed by N. A. Abdullah; E. S. K. Assem
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1990
- Tongue
- English
- Weight
- 254 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1420-908X
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Naive guinea-pigs were passively sensitized with varying amounts of affinity column purified, homologous, anti-ovalbumin IgG1 (anti-OA IgG1) and then examined for a) the capacity of lung tissue to release mediators (histamine and LTB4/LTD4) in response to antigen-challenge ex vivo and b) the attenda
Immunological sensitization of guinea-pigs and subsequent antigen inhalation challenge has provided an animal model which has several features in common with human asthma. Impairment of beta-adrenoceptor-mediated function and mechanisms have been postulated to contribute to the hyperreactivity to co