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Isapirone is a partial agonist at 5-hydroxytryptamine1A (5-HT1A) receptors in the rat hippocampus: electrophysiological evidence

✍ Scribed by Keith F. Martin; Robert Mason


Book ID
115880971
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
298 KB
Volume
141
Category
Article
ISSN
0014-2999

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The effects of a 5-HT1receptor ligand is
✍ G. M. Goodwin; Rosemarie J. Souza; A. R. Green πŸ“‚ Article πŸ“… 1986 πŸ› Springer 🌐 English βš– 557 KB

The effects of 2-(4-(4-(2-pyrimidinyl)-l-piperazinyl)-butyl)-1,2-benzoisothiazol-3(2H)one-1,1-dioxide hydrochloride (isapirone, TVX Q 7821), a putative 5-HT1 receptor antagonist, has been studied on various models of 5-HT receptor sub-type function. In mice TVX Q 7821 produced a dose-dependent inhib