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Isaacs’ syndrome associated with myasthenia gravis, showing remission after cytoreductive surgery of pleural recurrence of thymoma

✍ Scribed by Kazuhiro Fukushima; Toshio Sato; Shigeaki Mitsuhashi; Kazuma Kaneko; Masahide Yazaki; Masayuki Matsuda; Takao Hashimoto; Kazutoshi Hamanaka; Kazuo Yoshida; Shu-ichi Ikeda

Book ID: 116792721
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 205 KB
Volume: 16
Category: Article
ISSN: 0960-8966
DOI: 10.1016/j.nmd.2006.07.002

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T-cell-dependent B-cell help is likely to be of major importance in the pathogenesis of myasthenia gravis, but mechanisms provoking a pathological anti-acetylcholine receptor (AChR) response are poorly understood. We report on the dysregulation of recently identified CD4 ؊ /CD8 ؊ (double-negative) T