Is β2-microglobulin required for MHC class I heavy chain expression?
✍ Scribed by W. Lee Maloy; John E. Coligan
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 186 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0167-5699
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## Abstract Major histocompatibility complex (MHC) class I and II molecules present antigenic fragments to the immune system. MHC‐like chaperones, like HLA‐DM, HLA‐DO and tapasin support peptide loading. HLA class I heavy chains require association with β2‐microglobulin and peptide for endoplasmic
Mice lacking beta2-microglobulin (beta2m- mice) express greatly reduced levels of MHC class I molecules, and cells from beta2m- mice are therefore highly sensitive to NK cells. However, NK cells from beta2m- mice fail to kill beta2m- normal cells, showing that they are self tolerant. In a first atte