Is vestibular papillomatosis associated with human papillomavirus?

✍ Scribed by Silvano Costa; Antonella Rotola; Patrizia Terzano; Paola Secchiero; Dario Di Luca; Maria G. Poggi; Patrizia Masotti; Giuseppe Martinell; Dr. Enzo Cassai

• Book ID: 102909050
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 747 KB
• Volume: 35
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890350103

✦ Synopsis

Abstract

The origin and clinical significance of vestibular papillae were evaluated by comparing histological features with the presence of human papillomavirus (HPV) types 6/11 and 16/18, as revealed by Southern blot DNA hybridization. Twenty women with vestibular papillomatosis underwent clinical evaluation and follow‐up. When available, male partners were also examined. Histological changes suggestive of HPV infection were present in all the 20 specimens. Sixteen cases (80%) contained DNA sequences homologous to the viral probes. In particular, 12 cases (60%) reacted with the HPV 16/18 probe. Follow‐up for more than 18 months revealed no variation in the distribution and appearance of vestibular papillae. No male partner showed signs of HPV lesions. The study shows that HPV 16 is frequently associated with vestibular papillae but does not support a productive infection. Therefore the most appropriate management of these patients should be evaluated clinically in each individual case.