Is transthyretin (TTR) disrupted by a trinucleotide repeat expansion in a schizophrenia kindred?
โ Scribed by Goodman, Ann B.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 2 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(19980710)81:4<347::aid-ajmg13>3.0.co;2-l
No coin nor oath required. For personal study only.
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With the rationale that a disease that presents with anticipation could be associated with expansion of trinucleotide repeats, we selected parent-offspring pairs of schizophrenia patients with earlier age at onset in the filial generation to measure the expansion of CAG repeats using the repeat expa
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The fragile X syndrome of mental retardation is related to the number of trinucleotide CGG repeats at the 5-untranslated region of the FMR1 gene located on the X-chromosome. We have studied X-chromosomes from 649 unaffected Chinese subjects and 324 patients with mild mental retardation. All study su