Is Transposition of the Great Arteries a Consequence of Maternal Hormone Imbalance? Evidence from the Sex Ratios of Relatives of Probands

✍ Scribed by William H. James

• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 76 KB
• Volume: 198
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1006/jtbi.1999.0916

✦ Synopsis

Transposition of the great arteries occurs more often to males than females: moreover there is reportedly an excess of males among the unaffected relatives of probands. This is construed as evidence that maternal intrauterine hormone levels play a role in the aetiology of this malformation.