✦ LIBER ✦

Is there Replication-associated Mutational Pressure in the Saccharomyces cerevisiae Genome?

✍ Scribed by AGNIESZKA GIERLIK; MARIA KOWALCZUK; PAWEŁ MACKIEWICZ; MIROSŁAW R. DUDEK; STANISŁAW CEBRAT

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 373 KB
Volume: 202
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.1999.1062

No coin nor oath required. For personal study only.

✦ Synopsis

Compositional bias of yeast chromosomes was analysed using detrended DNA walks. Unlike eubacterial chromosomes, the yeast chromosomes did not show the specific asymmetry correlated with origin and terminus of replication. It is probably a result of a relative excess of autonomously replicating sequences (ARS) and of random choice of these sequences in each replication cycle. Nevertheless, the last ARS from both ends of chromosomes are responsible for unidirectional replication of subtelomeric sequences with pre-established leading/lagging roles of DNA strands. In these sequences a specific asymmetry is observed, resembling the asymmetry introduced by replication-associated mutational pressure into eubacterial chromosomes.

📜 SIMILAR VOLUMES

Running on empty: Does mitochondrial DNA

Running on empty: Does mitochondrial DNA mutation limit replicative lifespan in yeast? : Mutations that increase the division rate of cells lacking mitochondrial DNA also extend replicative lifespan in Saccharomyces cerevisiae

✍ Cory D. Dunn 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB 👁 2 views

## Abstract Mitochondrial DNA (mtDNA) mutations escalate with increasing age in higher organisms. However, it has so far been difficult to experimentally determine whether mtDNA mutation merely correlates with age or directly limits lifespan. A recent study shows that budding yeast can also lose fu