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Is there anticipation in the age at onset of cancer in families with Li-Fraumeni syndrome?

✍ Scribed by M. Trkova; M. Hladikova; P. Kasal; P. Goetz; Z. Sedlacek

Book ID: 106252801
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 53 KB
Volume: 47
Category: Article
ISSN: 1435-232X
DOI: 10.1007/s100380200055

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## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (N = 437 families). Families were subset as late‐onset (320 families, AAO ≥65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we