Is there a therapeutic window for plasma
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Koichi Otani; Sunao Kaneko; Hiroshi Sasa; Tsuyoshi Kondo; Yutaka Fukushima
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Article
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1991
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John Wiley and Sons
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English
β 469 KB
The relationship between clinical effects and plasma concentrations of mianserin and desmethylmianserin was studied in 29 cases of major depression during 3 weeks of mianserin treatment. The daily dose of mianserin was 30 mg in 27 cases and 20 mg in two cases. There was a significant U-shaped relati