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Is There a Rationale for Neuroprotection Against Dopamine Toxicity in Parkinson's Disease?

โœ Scribed by Ari Barzilai; Eldad Melamed; Anat Shirvan

Book ID
110296450
Publisher
Springer
Year
2001
Tongue
English
Weight
153 KB
Volume
21
Category
Article
ISSN
0272-4340

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Neurons in the substantia nigra may be vulnerable to oxidant stress because (a) the metabolism of dopamine generates peroxides. which, in the presence of iron. can lead to the formation of the highly reactive hydroxyl free radical; and (b) neuromelanin within nigral neurons can bind metals such as i