Is there a predisposition to malignancy when leukopenia is sustained during 6-mercaptopurine treatment of inflammatory bowel disease?

Hypoxanthine guanine phosphoribosyltrans

Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease

✍ Liang Ding; Fang-bin Zhang; Hui Liu; Xiang Gao; Hui-chang Bi; Xue-ding Wang; Bai 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 245 KB 👁 1 views

Background: Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is of importance for thiopurine metabolism and adverse events occurrence. The role of other thiopurine-metabolizing enzymes is less well kno