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Is there a phenotypic difference between probands in case-control versus family-based association studies?

✍ Scribed by Thomas G. Schulze; Sven Cichon; Markus M. Nöthen; Peter Propping; Wolfgang Maier; Marcella Rietschel

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 35 KB
Volume: 118B
Category: Article
ISSN: 1552-4841
DOI: 10.1002/ajmg.b.10060

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## Abstract Traditional case‐control genetic association studies utilizing unrelated probands are often used interchangeably with family‐based designs to detect genes for complex psychiatric disorders. This strategy may be limited, however, if significant phenotypic variation exists between proband