K-Ras mutant fraction in A/J mouse lung
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Fanxue Meng; Geremy W. Knapp; Terry Green; Jeffrey A. Ross; Barbara L. Parsons
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Article
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2009
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John Wiley and Sons
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English
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K-Ras mutant fraction (MF) was measured to examine the default assumption of low-dose linearity in the benzo[a]pyrene (B[a]P) mutational response. Groups of 10 male A/J mice (7- to 9-weeks old) received a single i.p. injection of 0, 0.05, 0.5, 5, or 50 mg/kg B[a]P and were sacrificed 28 days after t