✦ LIBER ✦

Is there a change in water proton density associated with functional magnetic resonance imaging?

✍ Scribed by Thies H. Jochimsen; David G. Norris; Harald E. Möller

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 121 KB
Volume: 53
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.20351

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✦ Synopsis

Abstract

In a recent series of studies (see, for example, Stroman et al. Magn Reson Imag 2001; 19:827–831), an increase of water proton density has been suggested to correlate with neuronal activity. Owing to the significant implications of such a mechanism for other functional experiments, the functional signal changes in humans at very short echo times were re‐examined by spin‐echo EPI at 3 T. The results do not confirm the previous hypothesis of a significant increase in extravascular proton density at TE = 0. Instead, an alternative explanation of the effect is offered: The use of a low threshold to identify activated voxels may generate an artificial offset in functional contrast due to the inclusion of false‐positives in the analysis. Magn Reson Med 53:470–473, 2005. © 2005 Wiley‐Liss, Inc.

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