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Is the need for analgesia influenced by the time of day?

✍ Scribed by Richard A. Steinbrook

Book ID
110907061
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
100 KB
Volume
41
Category
Article
ISSN
0001-5172

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The myelotoxicity of carboplatin is infl
The myelotoxicity of carboplatin is influenced by the time of its administration
✍ D. J. Kerr; C. Lewis; B. O'Neil; N. Lawson; R. G. Blackie; D. R. Newell; F. Boxa πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 329 KB

Previous studies have demonstrated that there are circadian rhythms in susceptibility to a range of commonly used cytotoxic drugs. In this study we have compared the pharmacokinetics and myelotoxicity of carboplatin administered at 18.00 and 06.00 in random order in patients with advanced ovarian ca