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Is the mitochondrial complex I ND5 gene a hot-spot for MELAS causing mutations?

โœ Scribed by Danae Liolitsa; Shamina Rahman; Sarah Benton; Lucinda J. Carr; Michael G. Hanna


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
707 KB
Volume
53
Category
Article
ISSN
0364-5134

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## Abstract Defects in NADH:ubiquinone oxidoreductase (complex I), the largest complex of the mitochondrial respiratory chain, account for most cases of respiratory chain deficiency in human. Complex I contains at least 45 subunits, 7 of which are encoded by mitochondrial DNA (mtDNA). Here we repor