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Is the metabolic syndrome a useful concept?

✍ Scribed by John Stanley

Publisher
Wiley (John Wiley & Sons)
Year
2007
Tongue
English
Weight
136 KB
Volume
19
Category
Article
ISSN
0956-666X

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✦ Synopsis

Abstract

The scientific literature is full of references to the metabolic syndrome. At present there are three separate sets of criteria for diagnosing this syndrome. While the same criteria are used in all three definitions the importance assigned to each is different. The WHO definition makes insulin resistance an essential criterion, the ATP III definition gives it equal weight to the other four criteria while the IDF definition makes it a non‐essential criterion. In addition, the role of body weight, body fat and body fat distribution is not clear. These three definitions of the metabolic syndrome have rather lost sight of Gerald Reaven's original formulation of syndrome X which was very clear that insulin resistance and its compensating hyperinsulinaemia are the causes of a variety of metabolic abnormalities which increase the risk of developing cardiovascular disease. Despite its popularity the metabolic syndrome is not a helpful concept.

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