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Is the FXR the fix for cholesterol gallstone disease?

โœ Scribed by Brian D. Juran; Konstantinos N. Lazaridis

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
384 KB
Volume
42
Category
Article
ISSN
0270-9139

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โœฆ Synopsis

Modulation of KC/gro protein (interleukin-8 related protein in rodents) release from hepatocytes by biologically active mediators.

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Two ATP-binding cassette (ABC) transporters, ABCG5 and ABCG8, have been proposed to limit sterol absorption and to promote biliary sterol excretion in humans. To test this hypothesis, a P1 clone containing the human ABCG5 and ABCG8 genes was used to generate transgenic mice. The transgenes were expr