Is the CACNA1A gene involved in familial migraine with aura?
β Scribed by R. Brugnoni; M. Leone; A. Rigamonti; E. Moranduzzo; F. Cornelio; R. Mantegazza; G. Bussone
- Publisher
- Springer Milan
- Year
- 2002
- Tongue
- English
- Weight
- 65 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1590-1874
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Migraine is a common neurological disease of two main types: migraine with aura and migraine without aura. Familial clustering suggests that genetic factors are involved in the etiology of migraine. Recently, a gene for familial hemiplegic migraine, a rare autosomal dominant subtype of migraine with
We searched for mutations in the voltagegated calcium channel gene, CACNA1A, in nine propositi of families with migraine headaches and episodic vertigo inherited in an autosomal dominant pattern. All 47 exons and flanking introns in CACNA1A were subjected to single-strand conformation polymorphism a