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Is the aminopyrine breath test a measure of microsomal function or of diffusional exchange in cirrhotic rat liver?


Book ID
123579052
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
79 KB
Volume
3
Category
Article
ISSN
0168-8278

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Differential regulation of liver P-450II
โœ Joseph C. Kolars; Scott A. Murray; Ken M. Peters; Paul B. Watkins ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 930 KB

Progressive liver fibrosis in rats develops when they are fed a diet deficient in choline. This diet also results in a pronounced and selective decrease in the liver microsomal content of a phase I drug-metabolizing enzyme belonging to the cytochrome P-450111 gene family. Because P-450111 cytochrome