𝔖 Bobbio Scriptorium
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Is telomerase activity in cancer due to selection of stem cells and differentiation arrest?

✍ Scribed by Mel Greaves


Book ID
113290150
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
198 KB
Volume
12
Category
Article
ISSN
0168-9525

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## Abstract The folate antagonist methotrexate (MTX) inhibits synthesis of tetrahydrofolate (THF), pyrimidines and purines, and induces differentiation in several cell types. At 1 Β΅M, MTX reduced proliferation and induced differentiation in HT29 colon cancer cells; the latter effect was augmented (