Is sex determination in germ line and soma controlled by separate genetic mechanisms?

The degradation of cell cycle regulators

The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease

✍ Diego F. Calvisi; Federico Pinna; Sara Ladu; Maria R. Muroni; Maddalena Frau; Il 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 560 KB

## Abstract Previous work showed a genetic control of cell cycle deregulation during hepatocarcinogenesis. We now evaluated in preneoplastic lesions, dysplastic nodules and hepatocellular carcinoma (HCC), chemically induced in genetically susceptible F344 and resistant Brown Norway (BN) rats, the r