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Is screening of blood donors for anti-HBc useful?

✍ Scribed by Caspari, G. ;Beyer, H. -J. ;Schmitt, H. ;Gerlich, W. ;Uy, A. ;Thomssen, R.


Book ID
105294333
Publisher
Springer-Verlag
Year
1990
Weight
194 KB
Volume
60
Category
Article
ISSN
1432-0584

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Anti-HBc IgM was determined by a modified radioimmunoassay (RIA) in 35 patients with acute hepatitis B, 35 patients with chronic hepatitis B (7 with chronic persistent, and 28 with chronic active hepatitis), 157 HBsAg positive blood donors, and in 143 HBsAg negative but anti-HBc positive donors. The

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Numerous tests to detect anti-HBc IgM have been developed and shown to have different degrees of sensitivity and specificity. One of these assays, Corzyme@-M (Abbott Laboratories, North Chicago, Ill.), recently became commercially available. The present study was undertaken to evaluate the clinical