๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Is medullary carcinoma of the breast hormone dependent?

โœ Scribed by J. K. Patel; T. Nemoto; T. L. Dao

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
170 KB
Volume
24
Category
Article
ISSN
0022-4790

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โœฆ Synopsis

From 1951 to 1981, 22 patients with metastatic medullary carcinoma of the breast were treated with hormonal therapies at Roswell Park Memorial Institute. Bilateral oophorectomy was performed in 6 premenopausal patients, and none had objective response, although one patient did have stable disease for 7 months. Three of these patients subsequently underwent bilateral adrenalectomy and none responded. Thirteen of 16 postmenopausal patients underwent bilateral adrenalectomy and only one had an objective response of 4 monlhs. Eight of 22 patients received additive hormones, and one patient was treated with Tamoxifen. There was no ob.jective response to these therapies. From this study, it appears that medullary carcinoma of the breast is less often responsive to endocrine therapy, and this finding correlates well with the recent data showing lower frequency of estrogen rcceptor-positive tumors in these patients.

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## Abstract ## BACKGROUND To investigate the role of primary hypothyroidism (HYPT) on breast carcinogenesis, the authors evaluated 1) the association between HYPT and a diagnosis of invasive breast carcinoma and 2) the clinicopathologic characteristics of breast carcinoma in patients with HYPT. #