Is laminin-1 a guidance cue for cerebellar granule cell migration?

✍ Scribed by Lom, Barbara ;Hockberger, Philip E.

• Book ID: 102655074
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 527 KB
• Volume: 33
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199707)33:1<72::aid-neu7>3.0.co;2-a

✦ Synopsis

Laminin-1 is a glycoprotein found with polylysine or tested in serum-containing medium. in the basement membrane of many tissues. In the Avoidance of laminin-1 regions in culture was not, cerebellum of rodents, it has also been localized along Bergmann glial fibers, where it is thought to be inhowever, blocked by pretreatment with laminin-1 volved in promoting granule cell migration by enhancantibodies. By comparison, mouse neuroblastoma ing adhesion and neurite outgrowth along these fibers. cells adhered preferentially to laminin-1 regions in Recent reports, however, indicate that laminin-1 is not serum-free medium, a response which was blocked present on Bergmann fibers, but instead is associated by laminin-1 antibodies. These results indicate that with blood vessels and meninges. Furthermore, atlaminin-1 is not involved in granule cell migration tempts to block granule cell migration using antibodalong Bergmann glial fibers. Instead, they suggest ies against laminin-1 have yielded conflicting results.

that laminin-1 may function as a repulsive guidance In this report, we provide further evidence that lamicue preventing granule cells from following inapnin-1 is associated exclusively with blood vessels and propriate pathways during development. ᭧ 1997 meninges in the cerebellum of postnatal rats. In addi-