𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Is Hsp90 a regulator of evolvability?

✍ Scribed by Wagner, G�nter P.; Chiu, Chi-Hua; Hansen, Thomas F.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
56 KB
Volume
285
Category
Article
ISSN
0022-104X

No coin nor oath required. For personal study only.

✦ Synopsis

In a recent paper, Rutherford and Lindquist (1998. Nature 396:336-342) identified mutations in the Hsp90 protein that act to unmask hidden genetic variation with a variety of phenotypic effects. The Hsp90 protein has a number of properties that suggest a role in regulating the expression of genetic variation and therefore in adjusting the evolvability of the organism. In this paper we reflect upon the evolutionary feasibility of such mechanisms and suggest some possible ways of testing the adaptation-for-evolvability hypothesis in more detail. We conclude that Hsp90 holds promise as a molecular model system for the evolution of evolvability.

📜 SIMILAR VOLUMES

Dengue virus entry into liver (HepG2) ce
Dengue virus entry into liver (HepG2) cells is independent of hsp90 and hsp70
✍ Arturo Cabrera-Hernandez; Chutima Thepparit; Lukkana Suksanpaisan; Duncan R. Smi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB

## Abstract Recently, several stress‐related proteins including GRP78, hsp70, and hsp90 have been implicated as dengue virus receptors in various cell types, with hsp90/70 being implicated as a receptor complex in monocytes and macrophages, while GRP78 has been implicated as a liver cell expressed

Regulation of metamorphosis in ascidians
Regulation of metamorphosis in ascidians involves NO/cGMP signaling and HSP90
✍ Bishop, Cory D. ;Bates, William R. ;Brandhorst, Bruce P. 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB

## Abstract Treatment of larvae of the ascidians __Boltenia villosa__ (Family: Pyuridae) and __Cnemidocarpa finmarkiensis__ (Family: Styelidae) with drugs that inhibit the function of the molecular chaperone HSP90 increased the frequency of tail resorption, the primary morphogenetic event of metamo

Only a small portion of the cytoplasmic
Only a small portion of the cytoplasmic progesterone receptor is associated with Hsp90 in vivo
✍ Satu Passinen; Marjaana Haverinen; Anu Pekki; Jenita Rauta; Jorma Paranko; Heimo 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB 👁 1 views

In cell extracts all of the nonliganded steroid receptor molecules are found as an oligomeric complex with Hsp90 and other proteins. In previous studies we have shown that Wild-type Hsp90 and progesterone receptor (PR) are located in different cell compartments (Tuohimaa et al. [1993] Proc. Natl. Ac

Diverse effects of Stat1 on the regulati
Diverse effects of Stat1 on the regulation of hsp90α gene under heat shock
✍ Xue-song Chen; Yi Zhang; Jin-shan Wang; Xiao-yan Li; Xiao-kuan Cheng; Ye Zhang; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

## Abstract Stat1 has been known as a regulator of gene expression and a mediator of IFNγ signaling in mammalian cells, while its effect in a heat shock response remains unclear. We used RNAi knockdown, point mutations, ChIP and promoter activity assays to study the effect of Stat1 on the heat‐shoc