Is fetal insulin secretion affected by fetal hypoxia?
โ Scribed by M Stangenberg; P Sasidharan
- Book ID
- 118890430
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 268 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0020-7292
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Whole fetal human pancreases of 12-22 weeks gestation, showed histological growth and differentiation in vitro over 3 weeks. At glucose concentrations of 1-4 g/l, there was no difference in insulin secretion into culture medium over 1 h. There was no stimulation of insulin release by D-glyceraldehyd
Recent studies suggest that NIDDM is linked with reduced fetal and infant growth. Observations on malnourished infants and studies of experimental animals exposed to protein energy or protein deficiency in fetal or early neonatal life suggest that the basis of this link could lie in the detrimental